Electronic(1)
6425
Madhyastha,M. S.
Novaczek,Irene
Ablett,R. F.
Johnson,Gerald R.
Nijjar,M. S.
Sims,David E.
In vitro study of domoic acid uptake by digestive gland tissue of blue mussel (Mytilus edulis L.)
Aquatic Toxicology
1991
20
1-2
73
82
Article Subject Terms: amino acids
digestive glands
seafood
human food
poisoning
Article Taxonomic Terms: Mytilus edulis
food poisoning
domoic acid
uptake
Canada, Prince Edward I.
foods
ANW, Canada, Prince Edward I.
Marine
Domoic acid is a neurotoxic amino acid responsible for an outbreak of human food poisoning in late 1987 following consumption of contaminated blue mussels (Mytilus edulis L.) from eastern Prince Edward Island, Canada. In vitro techniques were used to examine the uptake of domoic acid by digestive gland tissue of the blue mussel. Uptake of domoic acid over different periods of time by digestive gland tissue was compared with that of structurally related amino acids, glutamic acid and kainic acid. Domoic acid uptake was observed to be a function of time and concentration. Uptake of glutamic acid, which is a physiological amino acid, was greater than that of domoic acid. Kainic acid, a non-protein, rate amino acid, was least absorbed. In a series of experiments to determine the inhibitory actions of chemically similar and dissimilar amino acids, kainic acid, glutamic acid and proline inhibited the uptake of domoic acid by 42, 38 and 34%, respectively, indicating competition for the same carrier site.
0166-445X
Prince Edward Island Food Technol. Cent., Box 2000, Charlottetown, P.E.I. C1A 7N8, Canada
2605988
English; English
Q1 01266 Physiology, biochemistry, biophysics; Q3 01583 Shellfish culture; O 5060 Aquaculture; Q5 01524 Public health, medicines, dangerous organisms; P 1000 MARINE POLLUTION; X 24173 Animals
Journal Article; Toxicology Abstracts; Pollution Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources
ASFA 1: Biological Sciences and Living Resources
inovaczek
sims
gjohnson
Island Studies
Path Micro
Anatomy Physiology
Unknown(0)
NO_OBJ